Interesting Research

Significant advances have been made within the fields of regenerative medicine, inner ear otology, and neurophysiology in recent years. As a consequence, much research is being published on tinnitus, hearing loss, clinical trials, as well as novel compounds and interventions that aim to address some of the medical issues. The decision to include the research listed below was either because of the novelty of the science or that efficacy was (or was not) demonstrated in either an animal model or a human clinical trial. This section will be updated from time-to-time.

Tinnitus

●  Brain Metabolic Changes in Rats following Acoustic Trauma (DOI: dx.doi.org/10.3389/fnins.2017.00148)

●  Different Patterns of Hearing Loss among Tinnitus Patients: A Latent Class Analysis of a Large Sample (DOI: dx.doi.org/10.3389/fneur.2017.00046)

●  Stochastic Resonance Controlled Upregulation of Internal Noise after Hearing Loss as a Putative Cause of Tinnitus-Related Neuronal Hyperactivity (DOI: dx.doi.org/10.3389/fnins.2016.00597)

●  An Increase in Alpha Band Frequency in Resting State EEG after Electrical Stimulation of the Ear in Tinnitus Patients—A Pilot Study (DOI: dx.doi.org/10.3389/fnins.2016.00453)

●  Toward a Differential Diagnosis of Hidden Hearing Loss in Humans (DOI: dx.doi.org/10.1371/journal.pone.0162726)

●  Individualized Repetitive Transcranial Magnetic Stimulation Treatment in Chronic Tinnitus? (DOI: dx.doi.org/10.3389/fneur.2017.00126)

●  Efficacy and safety of AM-101 in the treatment of acute inner ear tinnitus--a double-blind, randomized, placebo-controlled phase II study (DOI: dx.doi.org/10.1097/MAO.0000000000000268)

●  Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series (DOI: dx.doi.org/10.1007/s00405-009-1126-1)

●  Mechanisms contributing to central excitability changes during hearing loss (DOI: dx.doi.org/10.1073/pnas.1116981109)

●  Frontostriatal Gating of Tinnitus and Chronic Pain (DOI: dx.doi.org/10.1016/j.tics.2015.08.002)

●  Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus (DOI: dx.doi.org/10.3389/fneur.2015.00124)

●  Tinnitus: causes and clinical management (DOI: dx.doi.org/10.1016/S1474-4422(13)70160-1)

Hearing Loss

●  The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss (DOI: dx.doi.org/10.1159/000441814)

●  Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: a double-blind, randomized, placebo-controlled phase II study (DOI: dx.doi.org/10.1097/MAO.0000000000000466)

●  Low-level laser therapy for prevention of noise-induced hearing loss in rats (DOI: dx.doi.org/10.1016/j.neulet.2015.03.031)

●  In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice (DOI: dx.doi.org/10.1016/j.celrep.2017.03.044)

●  The Cyclin Dependent Kinase Inhibitor p27Kip1 Maintains Terminal Differentiation in the Mouse Organ of Corti (DOI: dx.doi.org/10.2174/1874428101105010025])

●  Improvements in Sensorineural Hearing Loss After Cord Blood Transplant in Patients with Mucopolysaccharidosis (DOI: dx.doi.org/10.1001/jamaoto.2013.597)

Potassium Channel Openers

●  Pharmacodynamics of potassium channel openers in cultured neuronal networks (DOI: dx.doi.org/10.1016/j.ejphar.2014.03.017)

●  Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus (DOI: dx.doi.org/10.1523/JNEUROSCI.5176-14.2015)

●  Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators (DOI: dx.doi.org/10.1124/mol.115.103200)

●  Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus (DOI: dx.doi.org/10.1073/pnas.1302770110)

Stem Cells

●  Hearing restoration in a deaf animal model with intravenous transplantation of mesenchymal stem cells derived from human umbilical cord blood (DOI: dx.doi.org/10.1016/j.bbrc.2012.09.111)

●  Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss (DOI: dx.doi.org/10.1016/j.ijporl.2016.10.010)

●  The therapeutic efficacy of human adipose tissue-derived mesenchymal stem cells on experimental autoimmune hearing loss in mice (DOI: dx.doi.org/10.1111%2Fj.1365-2567.2011.03421.x)

●  Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration (DOI: dx.doi.org/10.1073/pnas.1501835112)

●  Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise (DOI: dx.doi.org/10.3727/096368908786092685)

Miscellaneous

●  Current strategies for drug delivery to the inner ear (DOI: dx.doi.org/10.1016/j.apsb.2013.02.003)

●  Relationship between tinnitus and suicidal behaviour in Korean men and women: a cross-sectional study (DOI: dx.doi.org/10.1111/coa.12500)

●  Maternal Prenatal Smoking and Hearing Loss Among Adolescents (DOI: dx.doi.org/10.1001/jamaoto.2013.3294)

 

Last date of revision: 17th May, 2017.